UMAP embedding of genetic dependencies of repair outcomes at Cas9-induced DSBs

The upper left panel summarizes the genetic dependencies of individual repair outcomes from screens at four different Cas9 target sites, as in Figure 3G here.
Outcomes are initially colored by the effect of a POLQ-targeting CRISPRi sgRNA on their frequencies.
Use the menu to the right to select different CRISRPi sgRNAs, or the tabs above to color outcomes by other properties.
The bottom panel shows the correlation in outcome frequency redistribution between the currently selected CRISPRi sgRNA and all other sgRNAs.
Mouse over points in the bottom panel to compare the effects of other sgRNAs.